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The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted

DNA replication in eukaryotic cells is tightly controlled by a licensing mechanism, ensuring that each origin fires once and only once per cell cycle. We demonstrate that the ataxia telangiectasia and Rad3 related (ATR)–mediated S phase checkpoint acts as a surveillance mechanism to prevent rereplic...

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Detalles Bibliográficos
Autores principales:	Liu, Enbo, Lee, Alan Yueh-Luen, Chiba, Takuya, Olson, Erin, Sun, Peiqing, Wu, Xiaohua
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080923/ https://www.ncbi.nlm.nih.gov/pubmed/18025301 http://dx.doi.org/10.1083/jcb.200704138

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