Functional Ablation of pRb Activates Cdk2 and Causes Antiestrogen Resistance in Human Breast Cancer Cells

Estrogens are required for the proliferation of hormone dependent breast cancer cells, making estrogen receptor (ER) positive tumors amenable to endocrine therapies such as antiestrogens. However, resistance to these agents remains a significant cause of treatment failure. We previously demonstrated...

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Detalles Bibliográficos
Autores principales: Varma, Hemant, Skildum, Andrew J., Conrad, Susan E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092387/
https://www.ncbi.nlm.nih.gov/pubmed/18060053
http://dx.doi.org/10.1371/journal.pone.0001256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092387/
https://www.ncbi.nlm.nih.gov/pubmed/18060053
http://dx.doi.org/10.1371/journal.pone.0001256

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