The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Human Skin

Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare disorder characterized by accelerated aging and early death, frequently from stroke or coronary artery disease. 90% of HGPS cases carry the LMNA G608G (GGC>GGT) mutation within exon 11 of LMNA, activating a splice donor site that...

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Detalles Bibliográficos
Autores principales: McClintock, Dayle, Ratner, Desiree, Lokuge, Meepa, Owens, David M., Gordon, Leslie B., Collins, Francis S., Djabali, Karima
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092390/
https://www.ncbi.nlm.nih.gov/pubmed/18060063
http://dx.doi.org/10.1371/journal.pone.0001269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092390/
https://www.ncbi.nlm.nih.gov/pubmed/18060063
http://dx.doi.org/10.1371/journal.pone.0001269

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