The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies

BACKGROUND: We studied linkage disequilibrium (LD) patterns at the BRCA1 locus, a susceptibility gene for breast and ovarian cancer, using a dense set of 114 single nucleotide polymorphisms in 5 population groups. We focused on Ashkenazi Jews in whom there are known founder mutations, to address the...

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Detalles Bibliográficos
Autores principales: Pereira, Lutécia H Mateus, Pineda, Marbin A, Rowe, William H, Fonseca, Libia R, Greene, Mark H, Offit, Kenneth, Ellis, Nathan A, Zhang, Jinghui, Collins, Andrew, Struewing, Jeffery P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2093936/
https://www.ncbi.nlm.nih.gov/pubmed/17916242
http://dx.doi.org/10.1186/1471-2156-8-68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2093936/
https://www.ncbi.nlm.nih.gov/pubmed/17916242
http://dx.doi.org/10.1186/1471-2156-8-68

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