NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer

The trans-activating responsive (TAR) RNA element located in the 5′ untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates transcription by interacting with both viral and cellular proteins. RNA hairpin aptamers specific for TAR were...

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Detalles Bibliográficos
Autores principales: Lebars, Isabelle, Richard, Tristan, Di Primo, Carmelo, Toulmé, Jean-Jacques
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094059/
https://www.ncbi.nlm.nih.gov/pubmed/17768146
http://dx.doi.org/10.1093/nar/gkm655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094059/
https://www.ncbi.nlm.nih.gov/pubmed/17768146
http://dx.doi.org/10.1093/nar/gkm655

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