Escherichia coli HU protein has a role in the repair of abasic sites in DNA

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HU is one of the most abundant DNA binding proteins in Escherichia coli. We find that it binds strongly to DNA containing an abasic (AP) site or tetrahydrofuran (THF) (apparent K(d) ≈50 nM). It also possesses an AP lyase activity that cleaves at a deoxyribose but not at a THF residue. The binding an...

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Detalles Bibliográficos
Autores principales: Kow, Yoke W., Imhoff, Barry, Weiss, Bernard, Hung, David C. I., Hindoyan, Antreas A., Story, Randall M., Goodman, Steven D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095813/
https://www.ncbi.nlm.nih.gov/pubmed/17916578
http://dx.doi.org/10.1093/nar/gkm567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095813/
https://www.ncbi.nlm.nih.gov/pubmed/17916578
http://dx.doi.org/10.1093/nar/gkm567

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