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Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP
Undifferentiated rat pheochromocytoma (PC12) cells extend neurites when cultured in the presence of nerve growth factor (NGF). Extracellular guanosine synergistically enhances NGF-dependent neurite outgrowth. We investigated the mechanism by which guanosine enhances NGF-dependent neurite outgrowth....
Autores principales: | Bau, Christian, Middlemiss, Pamela J., Hindley, Shaun, Jiang, Shucui, Ciccarelli, Renata, Caciagli, Francesco, DiIorio, Patrizia, Werstiuk, Eva S., Rathbone, Michel P. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096532/ https://www.ncbi.nlm.nih.gov/pubmed/18404501 http://dx.doi.org/10.1007/s11302-005-6214-0 |
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