Cargando…

Downregulation of CD94/NKG2A inhibitory receptors on CD8(+ )T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts

The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8(+ )T lymphocytes. Abnormal upregulation of the CD94/NKG2A inhibitory NKR on c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeddou, Mustapha, Rahmouni, Souad, Vandamme, Arnaud, Jacobs, Nathalie, Frippiat, Frédéric, Leonard, Philippe, Schaaf-Lafontaine, Nicole, Vaira, Dolores, Boniver, Jacques, Moutschen, Michel
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098781/ https://www.ncbi.nlm.nih.gov/pubmed/17927817 http://dx.doi.org/10.1186/1742-4690-4-72

Ejemplares similares

Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR
por: Henkens, Rachel, et al.
Publicado: (2008)

Recognition of the Class Ib Molecule Qa-1(b) by Putative Activating Receptors Cd94/Nkg2c and Cd94/Nkg2e on Mouse Natural Killer Cells
por: Vance, Russell E., et al.
Publicado: (1999)

Humanized mice as a useful model to study HIV-1 induced immune activation, its mechanisms and potential therapeutic approaches
por: Singh, Maneesh, et al.
Publicado: (2011)

Cytotoxicity of CD56(bright) NK Cells towards Autologous Activated CD4(+) T Cells Is Mediated through NKG2D, LFA-1 and TRAIL and Dampened via CD94/NKG2A
por: Nielsen, Natasja, et al.
Publicado: (2012)

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor
por: Brooks, Andrew G., et al.
Publicado: (1997)

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice
por: Shreeve, Norman, et al.
Publicado: (2021)

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence
por: Petrie, Emma J., et al.
Publicado: (2008)

A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
por: Michaëlsson, Jakob, et al.
Publicado: (2002)

Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease
por: Walsh, Ceara E., et al.
Publicado: (2011)

Targeting NKG2DL with Bispecific NKG2D–CD16 and NKG2D–CD3 Fusion Proteins on Triple–Negative Breast Cancer
por: Kaidun, Polina, et al.
Publicado: (2023)

Analysis of Qa-1(b)Peptide Binding Specificity and the Capacity of Cd94/Nkg2a to Discriminate between Qa-1–Peptide Complexes
por: Kraft, Jennifer R., et al.
Publicado: (2000)

Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System
por: Pupuleku, Aldi, et al.
Publicado: (2017)

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement
por: Wang, Xiaoli, et al.
Publicado: (2018)

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain
por: Hò, Gia-Gia T., et al.
Publicado: (2020)

Nonameric Peptide Orchestrates Signal Transduction in the Activating HLA-E/NKG2C/CD94 Immune Complex as Revealed by All-Atom Simulations
por: Prašnikar, Eva, et al.
Publicado: (2021)

High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation
por: Huisman, Brooke D., et al.
Publicado: (2023)

All-Atom Simulations Reveal the Intricacies of Signal Transduction upon Binding of the HLA-E Ligand to the Transmembrane Inhibitory CD94/NKG2A Receptor
por: Ljubič, Martin, et al.
Publicado: (2023)

Osteoarthritis Is a Low-Grade Inflammatory Disease: Obesity's Involvement and Herbal Treatment
por: Zeddou, Mustapha
Publicado: (2019)

All-Atom Simulations Reveal a Key Interaction Network in the HLA-E/NKG2A/CD94 Immune Complex Fine-Tuned by the Nonameric Peptide
por: Prašnikar, Eva, et al.
Publicado: (2021)

The nonclassical MHC class I Qa-1 expressed in layer 6 neurons regulates activity-dependent plasticity via microglial CD94/NKG2 in the cortex
por: Marin, Ioana A., et al.
Publicado: (2022)

Publisher Correction: High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation
por: Huisman, Brooke D., et al.
Publicado: (2023)

Bispecific NKG2D-CD3 and NKG2D-CD16 Fusion Proteins as Novel Treatment Option in Advanced Soft Tissue Sarcomas
por: Hagelstein, Ilona, et al.
Publicado: (2021)

Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia
por: Märklin, Melanie, et al.
Publicado: (2019)

Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium
por: De Voeght, Adrien, et al.
Publicado: (2017)

Mouse CD94/NKG2A Is a Natural Killer Cell Receptor for the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule Qa-1(b)
por: Vance, Russell E., et al.
Publicado: (1998)

What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes
por: Prašnikar, Eva, et al.
Publicado: (2022)

Upregulation of CD94 on CD8(+)T Cells in Anterior Chamber-Associated Immune Deviation
por: He, Hao, et al.
Publicado: (2008)

High-Density of FcγRIIIA(+) (CD16(+)) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis
por: Denis Musquer, Marie, et al.
Publicado: (2021)

Impact of coronavirus pandemic and containment measures on HIV diagnosis
por: Darcis, Gilles, et al.
Publicado: (2020)

Circulating NKG2A–NKG2D+ CD56dimCD16+ Natural Killer (NK) Cells as Mediators of Functional Immunosurveillance in Kidney Transplant Recipients
por: Zhu, Li, et al.
Publicado: (2020)

NKG2D(+)CD4(+) T Cells Kill Regulatory T Cells in a NKG2D-NKG2D Ligand- Dependent Manner in Systemic Lupus Erythematosus
por: Yang, Di, et al.
Publicado: (2017)

Development and Function of CD94-Deficient Natural Killer Cells
por: Orr, Mark T., et al.
Publicado: (2010)

An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2Rγ(NULL) Mice Allows HIV Replication and Development of Anti-HIV Immune Responses
por: Singh, Maneesh, et al.
Publicado: (2012)

Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patients
por: Shahbazi, Mehdi, et al.
Publicado: (2021)

Soluble NKG2D ligands impair CD8(+) T cell antitumor function dependent of NKG2D downregulation in neuroblastoma
por: Zhang, Yi, et al.
Publicado: (2023)

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation
por: Lelliott, Emily J., et al.
Publicado: (2022)

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells
por: Davis, Zachary B., et al.
Publicado: (2016)

Functional Dichotomy between NKG2D and CD28-Mediated Co-Stimulation in Human CD8(+) T Cells
por: Rajasekaran, Kamalakannan, et al.
Publicado: (2010)

CD8(+) T cells maintain killing of MHC-I-negative tumor cells through the NKG2D–NKG2DL axis
por: Lerner, Emily C., et al.
Publicado: (2023)

NKG2D(+) IFN-γ(+) CD8(+) T Cells Are Responsible for Palladium Allergy
por: Kawano, Mitsuko, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fvc515ukb43vpg01ppfa14ei1u