The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the coding region of the disease gene. This results in the production of a mutant protein with an abnormally expanded polyglutamine tract. Although these disorders have a...

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Detalles Bibliográficos
Autores principales: Davies, Janet E, Sarkar, Sovan, Rubinsztein, David C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106366/
https://www.ncbi.nlm.nih.gov/pubmed/18047739
http://dx.doi.org/10.1186/1471-2091-8-S1-S2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106366/
https://www.ncbi.nlm.nih.gov/pubmed/18047739
http://dx.doi.org/10.1186/1471-2091-8-S1-S2

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