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The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias
Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the coding region of the disease gene. This results in the production of a mutant protein with an abnormally expanded polyglutamine tract. Although these disorders have a...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106366/ https://www.ncbi.nlm.nih.gov/pubmed/18047739 http://dx.doi.org/10.1186/1471-2091-8-S1-S2 |