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THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES

Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilit...

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Detalles Bibliográficos
Autores principales: Maxwell, David S., Kruger, Lawrence
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1965
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106632/
https://www.ncbi.nlm.nih.gov/pubmed/19866658
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author Maxwell, David S.
Kruger, Lawrence
author_facet Maxwell, David S.
Kruger, Lawrence
author_sort Maxwell, David S.
collection PubMed
description Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilitate the identification of small processes and subpial and perivascular end-feet. Both protoplasmic and fibrous astrocytes contain cytoplasmic fibrils and should be distinguished on the basis of the configuration of their processes and their distribution. Acutely reactive astrocytes are characterized by a marked increase in the number of glycogen granules and mitochondria from the first day after irradiation. These cells later hypertrophy and accumulate lipid bodies and increased numbers of cytoplasmic fibrils. The glial "scar" consists of a greatly expanded volume of astrocyte cytoplasm filled with fibrils and displays no signs of astrocyte death, reversion to primitive forms, or extensive multiplication.
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spelling pubmed-21066322008-05-01 THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES Maxwell, David S. Kruger, Lawrence J Cell Biol Article Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilitate the identification of small processes and subpial and perivascular end-feet. Both protoplasmic and fibrous astrocytes contain cytoplasmic fibrils and should be distinguished on the basis of the configuration of their processes and their distribution. Acutely reactive astrocytes are characterized by a marked increase in the number of glycogen granules and mitochondria from the first day after irradiation. These cells later hypertrophy and accumulate lipid bodies and increased numbers of cytoplasmic fibrils. The glial "scar" consists of a greatly expanded volume of astrocyte cytoplasm filled with fibrils and displays no signs of astrocyte death, reversion to primitive forms, or extensive multiplication. The Rockefeller University Press 1965-05-01 /pmc/articles/PMC2106632/ /pubmed/19866658 Text en Copyright © 1965 by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Maxwell, David S.
Kruger, Lawrence
THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES
title THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES
title_full THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES
title_fullStr THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES
title_full_unstemmed THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES
title_short THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES
title_sort fine structure of astrocytes in the cerebral cortex and their response to focal injury produced by heavy ionizing particles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106632/
https://www.ncbi.nlm.nih.gov/pubmed/19866658
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