THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES

The renewal of protein in retinal rods and cones has been analyzed by quantitative electron microscope radioautography in adult frogs injected with a mixture of radioactive amino acids. Protein synthesis occurs predominantly in the ergastoplasm, localized in the myoid region of the photoreceptor cel...

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Autores principales: Young, Richard W., Droz, Bernard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107515/
https://www.ncbi.nlm.nih.gov/pubmed/5692679
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author Young, Richard W.
Droz, Bernard
author_facet Young, Richard W.
Droz, Bernard
author_sort Young, Richard W.
collection PubMed
description The renewal of protein in retinal rods and cones has been analyzed by quantitative electron microscope radioautography in adult frogs injected with a mixture of radioactive amino acids. Protein synthesis occurs predominantly in the ergastoplasm, localized in the myoid region of the photoreceptor cells. Much of the newly formed protein next flows through the Golgi complex. In rods, a large proportion of the protein then moves past the mitochondria of the ellipsoid segment, passes through the connecting cilium into the outer segment, and is there assembled into membranous discs at the base of that structure. Discs are formed at the rate of 36 per day in red rods and 25 per day in green rods at 22.5° C ambient temperature. In cones, a small proportion of the protein is similarly displaced to the outer segment. However, no new discs are formed. Instead, the protein becomes diffusely distributed throughout the cone outer segment. Low levels of radioactivity have been detected, shortly after injection, in the mitochondria, nucleus, and synaptic bodies of rods and cones. Nevertheless, in these organelles, the renewal process also appears to involve the utilization of protein formed in the ergastoplasm of the myoid.
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spelling pubmed-21075152008-05-01 THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES Young, Richard W. Droz, Bernard J Cell Biol Article The renewal of protein in retinal rods and cones has been analyzed by quantitative electron microscope radioautography in adult frogs injected with a mixture of radioactive amino acids. Protein synthesis occurs predominantly in the ergastoplasm, localized in the myoid region of the photoreceptor cells. Much of the newly formed protein next flows through the Golgi complex. In rods, a large proportion of the protein then moves past the mitochondria of the ellipsoid segment, passes through the connecting cilium into the outer segment, and is there assembled into membranous discs at the base of that structure. Discs are formed at the rate of 36 per day in red rods and 25 per day in green rods at 22.5° C ambient temperature. In cones, a small proportion of the protein is similarly displaced to the outer segment. However, no new discs are formed. Instead, the protein becomes diffusely distributed throughout the cone outer segment. Low levels of radioactivity have been detected, shortly after injection, in the mitochondria, nucleus, and synaptic bodies of rods and cones. Nevertheless, in these organelles, the renewal process also appears to involve the utilization of protein formed in the ergastoplasm of the myoid. The Rockefeller University Press 1968-10-01 /pmc/articles/PMC2107515/ /pubmed/5692679 Text en Copyright © 1968 by The Rockefeller University Press. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Young, Richard W.
Droz, Bernard
THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
title THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
title_full THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
title_fullStr THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
title_full_unstemmed THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
title_short THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
title_sort renewal of protein in retinal rods and cones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2107515/
https://www.ncbi.nlm.nih.gov/pubmed/5692679
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