Exchanging Murine and Human Immunoglobulin Constant Chains Affects the Kinetics and Thermodynamics of Antigen Binding and Chimeric Antibody Autoreactivity

Mouse-human chimeric antibodies composed of murine variable (V) and human (C) chains are useful therapeutic reagents. Consequently, we investigated whether heterologous C-regions from mice and humans affected specificity and affinity, and determined the contribution of C(H) glycosylation to antigen...

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Detalles Bibliográficos
Autores principales: Torres, Marcela, Fernandez-Fuentes, Narcis, Fiser, András, Casadevall, Arturo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110899/
https://www.ncbi.nlm.nih.gov/pubmed/18074033
http://dx.doi.org/10.1371/journal.pone.0001310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110899/
https://www.ncbi.nlm.nih.gov/pubmed/18074033
http://dx.doi.org/10.1371/journal.pone.0001310

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