Detection of Chromosomal Structural Alterations in Single Cells by SNP Arrays: A Systematic Survey of Amplification Bias and Optimized Workflow

BACKGROUND: In single-cell human genome analysis using whole-genome amplified product, a strong amplification bias involving allele dropout and preferential amplification hampers the quality of results. Using an oligonucleotide single nucleotide polymorphism (SNP) array, we systematically examined t...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwamoto, Kazuya, Bundo, Miki, Ueda, Junko, Nakano, Yoko, Ukai, Wataru, Hashimoto, Eri, Saito, Toshikazu, Kato, Tadafumi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111048/
https://www.ncbi.nlm.nih.gov/pubmed/18074030
http://dx.doi.org/10.1371/journal.pone.0001306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111048/
https://www.ncbi.nlm.nih.gov/pubmed/18074030
http://dx.doi.org/10.1371/journal.pone.0001306

Ejemplares similares