Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors are described. These inhibitors were designed and synthesized based upon our X-ray crystal structure of inhibitor 1 bound to...

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Detalles Bibliográficos
Autores principales: Ghosh, Arun K., Xi, Kai, Grum-Tokars, Valerie, Xu, Xiaoming, Ratia, Kiira, Fu, Wentao, Houser, Katherine V., Baker, Susan C., Johnson, Michael E., Mesecar, Andrew D.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2112940/
https://www.ncbi.nlm.nih.gov/pubmed/17855091
http://dx.doi.org/10.1016/j.bmcl.2007.08.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2112940/
https://www.ncbi.nlm.nih.gov/pubmed/17855091
http://dx.doi.org/10.1016/j.bmcl.2007.08.031

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