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Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor
Two conditions were identified that interfered with the complex polymerization process in biosynthesis of von Willebrand factor (vWf). Treatment of human umbilical vein endothelial cells with tunicamycin inhibited N-linked glycosylation of nascent vWf and the resulting pro- vWf monomers failed to di...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1986
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114173/ https://www.ncbi.nlm.nih.gov/pubmed/3082891 |