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Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells
The twofold purpose of the study was (a) to determine if a MAP-1-like protein was expressed in human prostatic DU 145 cells and (b) to demonstrate whether a novel antimicrotubule drug, estramustine, binds the MAP-1-like protein to disrupt microtubules. SDS-PAGE and Western blots showed that a 330-kD...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1988
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115649/ https://www.ncbi.nlm.nih.gov/pubmed/3060470 |