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Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast
BiP/GRP78 is an essential member of the HSP70 family that resides in the lumen of the endoplasmic reticulum. In yeast, BiP/GRP78 is encoded by the KAR2 gene. A temperature sensitive mutation was isolated in KAR2 and found to cause a rapid block in protein secretion. Secretory precursors of a number...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1990
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2116122/ https://www.ncbi.nlm.nih.gov/pubmed/2190988 |