Nitrosylcobalamin Potentiates the Anti-Neoplastic Effects of Chemotherapeutic Agents via Suppression of Survival Signaling

BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. NO-Cbl induces Apo2L/TRAIL-mediated apoptosis and inhibits survival signaling in a variety of malign...

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Detalles Bibliográficos
Autores principales: Bauer, Joseph A., Lupica, Joseph A., Schmidt, Heidi, Morrison, Bei H., Haney, Rebecca M., Masci, Rhonda K., Lee, Rebecca M., DiDonato, Joseph A., Lindner, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117345/
https://www.ncbi.nlm.nih.gov/pubmed/18074035
http://dx.doi.org/10.1371/journal.pone.0001313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117345/
https://www.ncbi.nlm.nih.gov/pubmed/18074035
http://dx.doi.org/10.1371/journal.pone.0001313

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