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Nitrosylcobalamin Potentiates the Anti-Neoplastic Effects of Chemotherapeutic Agents via Suppression of Survival Signaling

BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. NO-Cbl induces Apo2L/TRAIL-mediated apoptosis and inhibits survival signaling in a variety of malign...

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Detalles Bibliográficos
Autores principales:	Bauer, Joseph A., Lupica, Joseph A., Schmidt, Heidi, Morrison, Bei H., Haney, Rebecca M., Masci, Rhonda K., Lee, Rebecca M., DiDonato, Joseph A., Lindner, Daniel J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117345/ https://www.ncbi.nlm.nih.gov/pubmed/18074035 http://dx.doi.org/10.1371/journal.pone.0001313

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