Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

The polycomb group (PcG) protein Bmi1 plays an essential role in the self-renewal of hematopoietic and neural stem cells. Derepression of the Ink4a/Arf gene locus has been largely attributed to Bmi1-deficient phenotypes in the nervous system. However, its role in hematopoietic stem cell (HSC) self-r...

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Detalles Bibliográficos
Autores principales: Oguro, Hideyuki, Iwama, Atsushi, Morita, Yohei, Kamijo, Takehiko, van Lohuizen, Maarten, Nakauchi, Hiromitsu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118102/
https://www.ncbi.nlm.nih.gov/pubmed/16954369
http://dx.doi.org/10.1084/jem.20052477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118102/
https://www.ncbi.nlm.nih.gov/pubmed/16954369
http://dx.doi.org/10.1084/jem.20052477

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