Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

The programmed death (PD)-1–PD-1 ligand (PD-L) pathway, which is part of the B7–CD28 family, consists of the PD-1 receptor and its two ligands PD-L1 and PD-L2. Engagement of PD-1 by its ligands inhibits immune responses, and recent work has shown that PD-1 is highly expressed on exhausted T cells du...

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Detalles Bibliográficos
Autores principales: Freeman, Gordon J., Wherry, E. John, Ahmed, Rafi, Sharpe, Arlene H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118103/
https://www.ncbi.nlm.nih.gov/pubmed/17000870
http://dx.doi.org/10.1084/jem.20061800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118103/
https://www.ncbi.nlm.nih.gov/pubmed/17000870
http://dx.doi.org/10.1084/jem.20061800

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