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Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118108/ https://www.ncbi.nlm.nih.gov/pubmed/17000868 http://dx.doi.org/10.1084/jem.20060998 |
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author | Guidos, Cynthia J. |
author_facet | Guidos, Cynthia J. |
author_sort | Guidos, Cynthia J. |
collection | PubMed |
description | Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling is not essential for pre–T cell receptor (TCR) expression or γδ lineage choice. Rather, pre-TCR signaling enhances progenitor competitiveness for limiting Notch ligands, leading to preferential expansion of TCRβ-bearing progenitors. |
format | Text |
id | pubmed-2118108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21181082007-12-13 Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice Guidos, Cynthia J. J Exp Med Commentaries Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling is not essential for pre–T cell receptor (TCR) expression or γδ lineage choice. Rather, pre-TCR signaling enhances progenitor competitiveness for limiting Notch ligands, leading to preferential expansion of TCRβ-bearing progenitors. The Rockefeller University Press 2006-10-02 /pmc/articles/PMC2118108/ /pubmed/17000868 http://dx.doi.org/10.1084/jem.20060998 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Commentaries Guidos, Cynthia J. Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice |
title | Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice |
title_full | Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice |
title_fullStr | Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice |
title_full_unstemmed | Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice |
title_short | Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice |
title_sort | synergy between the pre–t cell receptor and notch: cementing the αβ lineage choice |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118108/ https://www.ncbi.nlm.nih.gov/pubmed/17000868 http://dx.doi.org/10.1084/jem.20060998 |
work_keys_str_mv | AT guidoscynthiaj synergybetweenthepretcellreceptorandnotchcementingtheablineagechoice |