Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice

Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling...

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Detalles Bibliográficos
Autor principal: Guidos, Cynthia J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118108/
https://www.ncbi.nlm.nih.gov/pubmed/17000868
http://dx.doi.org/10.1084/jem.20060998
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author Guidos, Cynthia J.
author_facet Guidos, Cynthia J.
author_sort Guidos, Cynthia J.
collection PubMed
description Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling is not essential for pre–T cell receptor (TCR) expression or γδ lineage choice. Rather, pre-TCR signaling enhances progenitor competitiveness for limiting Notch ligands, leading to preferential expansion of TCRβ-bearing progenitors.
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spelling pubmed-21181082007-12-13 Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice Guidos, Cynthia J. J Exp Med Commentaries Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling is not essential for pre–T cell receptor (TCR) expression or γδ lineage choice. Rather, pre-TCR signaling enhances progenitor competitiveness for limiting Notch ligands, leading to preferential expansion of TCRβ-bearing progenitors. The Rockefeller University Press 2006-10-02 /pmc/articles/PMC2118108/ /pubmed/17000868 http://dx.doi.org/10.1084/jem.20060998 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Guidos, Cynthia J.
Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
title Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
title_full Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
title_fullStr Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
title_full_unstemmed Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
title_short Synergy between the pre–T cell receptor and Notch: cementing the αβ lineage choice
title_sort synergy between the pre–t cell receptor and notch: cementing the αβ lineage choice
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118108/
https://www.ncbi.nlm.nih.gov/pubmed/17000868
http://dx.doi.org/10.1084/jem.20060998
work_keys_str_mv AT guidoscynthiaj synergybetweenthepretcellreceptorandnotchcementingtheablineagechoice

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