Cargando…

T cell receptor for antigen induces linker for activation of T cell–dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

Adaptor proteins positively or negatively regulate the T cell receptor for antigen (TCR) signaling cascade. We report that after TCR stimulation, the inhibitory adaptor downstream of kinase (Dok)-2 and its homologue Dok-1 are involved in a multimolecular complex including the lipid phosphatase Src h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Shen, Corre, Béatrice, Foulon, Eliane, Dufour, Evelyne, Veillette, André, Acuto, Oreste, Michel, Frédérique
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118126/ https://www.ncbi.nlm.nih.gov/pubmed/17043143 http://dx.doi.org/10.1084/jem.20060650

Ejemplares similares

Role of Dok-1 and Dok-2 in Leukemia Suppression
por: Niki, Masaru, et al.
Publicado: (2004)

Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
por: Shinohara, Hisaaki, et al.
Publicado: (2005)

Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia
por: Yasuda, Tomoharu, et al.
Publicado: (2004)

Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice
por: OHSUGI, Takeo
Publicado: (2017)

The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
por: Seiler, Caroline, et al.
Publicado: (2022)

A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76
por: Bartolo, Vincenzo Di, et al.
Publicado: (2007)

Expression and significance of DOK2 in colorectal cancer
por: WEN, XIANMEI, et al.
Publicado: (2015)

DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84
por: Gao, Wen-Shuang, et al.
Publicado: (2020)

DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma
por: Berger, Alice H., et al.
Publicado: (2013)

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation
por: Grimm, Jan, et al.
Publicado: (2001)

Grb2 binding induces phosphorylation-independent activation of Shp2
por: Lin, Chi-Chuan, et al.
Publicado: (2021)

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
por: Moraes, L A, et al.
Publicado: (2010)

Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells
por: Vanshylla, Kanika, et al.
Publicado: (2018)

Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses
por: de Wet, Ben, et al.
Publicado: (2011)

Co-expression and significance of Dok2 and Ras p21 protein activator 1 in breast cancer
por: Huang, Jiangrong, et al.
Publicado: (2017)

The Macronova in GRB 050709 and the GRB-macronova connection
por: Jin, Zhi-Ping, et al.
Publicado: (2016)

Molecular T Cell Biology – Basic and Translational Challenges in the Twenty-First Century
por: Reinherz, Ellis L., et al.
Publicado: (2011)

Long-term muscle-specific overexpression of DOK7 in mice using AAV9-tMCK-DOK7
por: Huang, Yu-Ting, et al.
Publicado: (2023)

Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression
por: Siouda, Maha, et al.
Publicado: (2014)

Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
por: Nocka, Laura M, et al.
Publicado: (2023)

Expression and clinical significance of DOK3 in renal clear cell carcinoma
por: Wang, Yi-Fan, et al.
Publicado: (2023)

Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer
por: Lara, Olivia D., et al.
Publicado: (2020)

A Computational Analysis of the Dynamic Roles of Talin, Dok1, and PIPKI for Integrin Activation
por: Geier, Florian, et al.
Publicado: (2011)

Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity
por: Ng, Khong Y., et al.
Publicado: (2014)

A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells
por: Zhang, Shaochuan, et al.
Publicado: (2022)

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
por: Ahmed, Zamal, et al.
Publicado: (2013)

Tyrosine phosphorylation of Grb14 by Tie2
por: Sturk, Celina, et al.
Publicado: (2010)

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1
por: Qu, Yingying, et al.
Publicado: (2014)

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading
por: Woodring, Pamela J., et al.
Publicado: (2004)

ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors
por: Fitzgerald, Lily M., et al.
Publicado: (2016)

Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma
por: Li, Chen-xi, et al.
Publicado: (2022)

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation
por: Law, Che-Leung, et al.
Publicado: (1999)

DOK7 gene therapy enhances motor activity and life span in ALS model mice
por: Miyoshi, Sadanori, et al.
Publicado: (2017)

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production
por: Bilal, Mahmood Yousif, et al.
Publicado: (2015)

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
por: Bongartz, Hannes, et al.
Publicado: (2019)

Quantitative Contribution of CD4 and CD8 to T Cell Antigen Receptor Serial Triggering
por: Viola, Antonella, et al.
Publicado: (1997)

2nd Gamma-Ray Burst Workshop - GRB 2
por: Brainerd, J J, et al.
Publicado: (1994)

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites
por: Gugasyan, Raffi, et al.
Publicado: (2002)

Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons
por: Murase, Sachiko
Publicado: (2015)

Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation
por: Yoshizawa, Ryo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j59ruuvr16um8g9g2tqooe9gr0