Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

The expression of self-antigen in the thymus is believed to be responsible for the deletion of autoreactive T lymphocytes, a critical process in the maintenance of unresponsiveness to self. The Autoimmune regulator (Aire) gene, which is defective in the disorder autoimmune polyglandular syndrome typ...

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Detalles Bibliográficos
Autores principales: DeVoss, Jason, Hou, Yafei, Johannes, Kellsey, Lu, Wen, Liou, Gregory I., Rinn, John, Chang, Howard, Caspi, Rachel, Fong, Lawrence, Anderson, Mark S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118158/
https://www.ncbi.nlm.nih.gov/pubmed/17116738
http://dx.doi.org/10.1084/jem.20061864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118158/
https://www.ncbi.nlm.nih.gov/pubmed/17116738
http://dx.doi.org/10.1084/jem.20061864

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