A checkpoint for autoreactivity in human IgM(+) memory B cell development

Autoantibodies are removed from the repertoire at two checkpoints during B cell development in the bone marrow and the periphery. Despite these checkpoints, up to 20% of the antibodies expressed by mature naive B cells in healthy humans show low levels of self-reactivity. To determine whether self-r...

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Detalles Bibliográficos
Autores principales: Tsuiji, Makoto, Yurasov, Sergey, Velinzon, Klara, Thomas, Saskia, Nussenzweig, Michel C., Wardemann, Hedda
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118214/
https://www.ncbi.nlm.nih.gov/pubmed/16446381
http://dx.doi.org/10.1084/jem.20052033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118214/
https://www.ncbi.nlm.nih.gov/pubmed/16446381
http://dx.doi.org/10.1084/jem.20052033

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