T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription

T helper type 1 (Th1) development is facilitated by interrelated changes in key intracellular factors, particularly signal transducer and activator of transcription (STAT)4, T-bet, and GATA-3. Here we show that CD4(+) cells from T-bet(−/−) mice are skewed toward Th2 differentiation by high endogenou...

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Detalles Bibliográficos
Autores principales: Usui, Takashi, Preiss, Jan C., Kanno, Yuka, Yao, Zheng Ju, Bream, Jay H., O'Shea, John J., Strober, Warren
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118252/
https://www.ncbi.nlm.nih.gov/pubmed/16520391
http://dx.doi.org/10.1084/jem.20052165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118252/
https://www.ncbi.nlm.nih.gov/pubmed/16520391
http://dx.doi.org/10.1084/jem.20052165

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