In vivo analysis of the role of aberrant histone deacetylase recruitment and RARα blockade in the pathogenesis of acute promyelocytic leukemia

The promyelocytic leukemia–retinoic acid receptor α (PML-RARα) protein of acute promyelocytic leukemia (APL) is oncogenic in vivo. It has been hypothesized that the ability of PML-RARα to inhibit RARα function through PML-dependent aberrant recruitment of histone deacetylases (HDACs) and chromatin r...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsushita, Hiromichi, Scaglioni, Pier Paolo, Bhaumik, Mantu, Rego, Eduardo M., Cai, Lu Fan, Majid, Samia M., Miyachi, Hayato, Kakizuka, Akira, Miller, Wilson H., Pandolfi, Pier Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118271/
https://www.ncbi.nlm.nih.gov/pubmed/16549595
http://dx.doi.org/10.1084/jem.20050616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118271/
https://www.ncbi.nlm.nih.gov/pubmed/16549595
http://dx.doi.org/10.1084/jem.20050616

Ejemplares similares