Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate

Thymic precursors expressing the pre–T cell receptor (TCR), the γδTCR, or the αβTCR can all enter the CD4(+)8(+) αβ lineage, albeit with different efficacy. Here it is shown that proliferation and differentiation of precursors with the different TCRs into αβ lineage cells require Notch signaling at...

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Detalles Bibliográficos
Autores principales: Garbe, Annette I., Krueger, Andreas, Gounari, Fotini, Zúñiga-Pflücker, Juan Carlos, von Boehmer, Harald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118312/
https://www.ncbi.nlm.nih.gov/pubmed/16754723
http://dx.doi.org/10.1084/jem.20060474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118312/
https://www.ncbi.nlm.nih.gov/pubmed/16754723
http://dx.doi.org/10.1084/jem.20060474

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