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Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
Thymic precursors expressing the pre–T cell receptor (TCR), the γδTCR, or the αβTCR can all enter the CD4(+)8(+) αβ lineage, albeit with different efficacy. Here it is shown that proliferation and differentiation of precursors with the different TCRs into αβ lineage cells require Notch signaling at...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118312/ https://www.ncbi.nlm.nih.gov/pubmed/16754723 http://dx.doi.org/10.1084/jem.20060474 |