Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help

In K/BxN mice, arthritis is induced by autoantibodies against glucose-6-phosphate-isomerase (GPI). To investigate B cell tolerance to GPI in nonautoimmune mice, we increased the GPI-reactive B cell frequency using a low affinity anti-GPI H chain transgene. Surprisingly, anti-GPI B cells were not tol...

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Detalles Bibliográficos
Autores principales: Mandik-Nayak, Laura, Racz, Jennifer, Sleckman, Barry P., Allen, Paul M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118363/
https://www.ncbi.nlm.nih.gov/pubmed/16880262
http://dx.doi.org/10.1084/jem.20060701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118363/
https://www.ncbi.nlm.nih.gov/pubmed/16880262
http://dx.doi.org/10.1084/jem.20060701

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