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Neutrophils from p40(phox−/−) mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

The generation of reactive oxygen species (ROS) by the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex plays a critical role in the antimicrobial functions of the phagocytic cells of the immune system. The catalytic core of this oxidase consists of a complex between gp91(...

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Detalles Bibliográficos
Autores principales: Ellson, Chris D., Davidson, Keith, Ferguson, G. John, O'Connor, Rod, Stephens, Len R., Hawkins, Phillip T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118373/
https://www.ncbi.nlm.nih.gov/pubmed/16880254
http://dx.doi.org/10.1084/jem.20052069