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The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 (−/−) ung (−/−) mice
Immunoglobulin (Ig) class switching is initiated by deamination of C→U within the immunoglobulin heavy chain locus, catalyzed by activation-induced deaminase (AID). In the absence of uracil-DNA glycosylase (UNG) and the homologue of bacterial MutS (MSH)–2 mismatch recognition protein, the resultant...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118391/ https://www.ncbi.nlm.nih.gov/pubmed/16894013 http://dx.doi.org/10.1084/jem.20061067 |