Cargando…

Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8(+) T cell response

CD8(+) T cells only require a brief stimulation with antigen in vitro to divide and differentiate into effector and memory cells upon transfer in vivo. The efficiency of clonal expansion and the functional characteristics of memory cells derived from briefly stimulated cells are poorly defined. We d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prlic, Martin, Hernandez-Hoyos, Gabriela, Bevan, Michael J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118397/ https://www.ncbi.nlm.nih.gov/pubmed/16908626 http://dx.doi.org/10.1084/jem.20060928

Ejemplares similares

CD8β Increases CD8 Coreceptor Function and Participation in TCR–Ligand Binding
por: Renard, Valery, et al.
Publicado: (1996)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
por: Duong, Minh Ngoc, et al.
Publicado: (2019)

Development and function of natural TCR(+) CD8αα(+) intraepithelial lymphocytes
por: Gui, Yuanyuan, et al.
Publicado: (2022)

Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
por: Bajwa, Gagan, et al.
Publicado: (2020)

Contrasted TCRβ Diversity of CD8(+) and CD8(−) T Cells in Rainbow Trout
por: Castro, Rosario, et al.
Publicado: (2013)

Post-stimulus beta responses are modulated by task duration
por: Pakenham, Daisie O., et al.
Publicado: (2020)

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
Publicado: (1995)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

The timing, duration and magnitude of the 8.2 ka event in global speleothem records
por: Parker, Sarah E., et al.
Publicado: (2022)

CD137 (4-1BB) costimulation of CD8(+) T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
por: Otano, Itziar, et al.
Publicado: (2021)

Hypotensive Response Magnitude and Duration in Hypertensives: Continuous and Interval Exercise
por: de Carvalho, Raphael Santos Teodoro, et al.
Publicado: (2015)

T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4(+) T Cell Response in Vivo
por: Fassò, Marcella, et al.
Publicado: (2000)

CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells
por: Cho, Jae-Ho, et al.
Publicado: (2016)

Distinct Features of Canine Non-conventional CD4(−)CD8α(−) Double-Negative TCRαβ(+) vs. TCRγδ(+) T Cells
por: Rabiger, Friederike V., et al.
Publicado: (2019)

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity
por: Hao, Yi, et al.
Publicado: (2006)

Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells()
por: Borger, Jessica G., et al.
Publicado: (2014)

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor
por: Casas, Javier, et al.
Publicado: (2014)

Cish attenuates proximal TCR-signaling and CD8+ T cell immunity
por: Palmer, Douglas, et al.
Publicado: (2014)

Various Stages of Immune Synapse Formation Are Differently Dependent on the Strength of the TCR Stimulus
por: Estl, Michael, et al.
Publicado: (2020)

Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
por: Presotto, Danilo, et al.
Publicado: (2017)

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude
por: Quinn, Kylie M., et al.
Publicado: (2017)

The influence of stimulus duration on olfactory perception
por: Kuruppath, Praveen, et al.
Publicado: (2021)

Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study
por: Kawano, Yasuhiro, et al.
Publicado: (2021)

Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells
por: Jiang, Jiu, et al.
Publicado: (2013)

CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha- beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells
Publicado: (1994)

Enhancing Efficacy of TCR-engineered CD4(+) T Cells Via Coexpression of CD8α
por: Anderson, Victoria E., et al.
Publicado: (2023)

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
Publicado: (1991)

Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness
por: Eggert, Joel, et al.
Publicado: (2023)

COVID‐19 and anatomy: Stimulus and initial response
por: Brassett, Cecilia, et al.
Publicado: (2020)

Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations
por: Xiao, Lei, et al.
Publicado: (2014)

CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine
por: Cho, Hyoung-Soo, et al.
Publicado: (2020)

Evolution of CD8(+) T Cell Receptor (TCR) Engineered Therapies for the Treatment of Cancer
por: Sun, Yimo, et al.
Publicado: (2021)

Intravenous administration of viral vectors expressing prostate cancer antigens enhances the magnitude and functionality of CD8+ T cell responses
por: Vardeu, Antonella, et al.
Publicado: (2022)

Inter-Trial Variability in Sensory-Evoked Cortical Hemodynamic Responses: The Role of the Magnitude of Pre-Stimulus Fluctuations
por: Saka, Mohamad, et al.
Publicado: (2012)

Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4(+) T Cells
por: van Loenen, Marleen M., et al.
Publicado: (2013)

The Duration of Motor Responses Evoked with Intracortical Microstimulation in Rats Is Primarily Modulated by Stimulus Amplitude and Train Duration
por: Watson, Meghan, et al.
Publicado: (2016)

Effect of the Stimulus Duration on the Adaptation of the Optokinetic Afternystagmus
por: Gygli, Jan, et al.
Publicado: (2021)

The magnitude of the sound-induced flash illusion does not increase monotonically as a function of visual stimulus eccentricity
por: Gavin, Niall, et al.
Publicado: (2022)

n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR–pMHC Interaction of Anti-Viral CD8(+) T Cells
por: Lim, Younghyun, et al.
Publicado: (2020)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_ajj0kijqbm24kvf18pu6ll4obk