A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant

Activation of naive T cells requires the integration of signals through the antigen receptor and CD28. Although there is agreement on the importance of CD28, there remains controversy on the mechanism by which CD28 regulates T cell function. We have generated a gene-targeted knockin mouse expressing...

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Detalles Bibliográficos
Autores principales: Friend, Lindzy D., Shah, Dulari D., Deppong, Christine, Lin, Joseph, Bricker, Traci L., Juehne, Twyla I., Rose, Christine M., Green, Jonathan M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118406/
https://www.ncbi.nlm.nih.gov/pubmed/16908623
http://dx.doi.org/10.1084/jem.20052230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118406/
https://www.ncbi.nlm.nih.gov/pubmed/16908623
http://dx.doi.org/10.1084/jem.20052230

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