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An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response
Cross-linking of the FcɛRI activates the phosphatidyl inositol 3 kinase (PI3K) and mitogen-activated protein kinase pathways. Previous studies demonstrate that Ras guanyl nucleotide-releasing protein (RasGRP)1 is essential in T cell receptor–mediated Ras-Erk activation. Here, we report that RasGRP1...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118421/ https://www.ncbi.nlm.nih.gov/pubmed/17190838 http://dx.doi.org/10.1084/jem.20061598 |