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Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T

Somatic hypermutation (SHM) introduces nucleotide substitutions into immunoglobulin variable (Ig V) region genes at all four bases, but the mutations at C/G and A/T pairs are achieved by distinct mechanisms. Mutations at C/G pairs are a direct consequence of the C→U deamination catalyzed by activati...

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Detalles Bibliográficos
Autores principales: Neuberger, Michael S., Rada, Cristina
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118430/
https://www.ncbi.nlm.nih.gov/pubmed/17190841
http://dx.doi.org/10.1084/jem.20062409