Cargando…
Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T
Somatic hypermutation (SHM) introduces nucleotide substitutions into immunoglobulin variable (Ig V) region genes at all four bases, but the mutations at C/G and A/T pairs are achieved by distinct mechanisms. Mutations at C/G pairs are a direct consequence of the C→U deamination catalyzed by activati...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118430/ https://www.ncbi.nlm.nih.gov/pubmed/17190841 http://dx.doi.org/10.1084/jem.20062409 |