Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C

Activated protein C (APC) reduces mortality of severe sepsis patients but increases the risk of serious bleeding. APC exerts anticoagulant activity by proteolysis of factors Va/VIIIa. APC also exerts antiinflammatory and antiapoptotic effects and stabilizes endothelial barrier function by APC-initia...

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Detalles Bibliográficos
Autores principales: Kerschen, Edward J., Fernandez, José A., Cooley, Brian C., Yang, Xia V., Sood, Rashmi, Mosnier, Laurent O., Castellino, Francis J., Mackman, Nigel, Griffin, John H., Weiler, Hartmut
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118455/
https://www.ncbi.nlm.nih.gov/pubmed/17893198
http://dx.doi.org/10.1084/jem.20070404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118455/
https://www.ncbi.nlm.nih.gov/pubmed/17893198
http://dx.doi.org/10.1084/jem.20070404

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