Cross-presentation of glycolipid from tumor cells loaded with α-galactosylceramide leads to potent and long-lived T cell–mediated immunity via dendritic cells

We report a mechanism to induce combined and long-lived CD4(+) and CD8(+) T cell immunity to several mouse tumors. Surprisingly, the initial source of antigen is a single low dose of tumor cells loaded with α-galactosylceramide (α-GalCer) glycolipid (tumor/Gal) but lacking co-stimulatory molecules....

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Detalles Bibliográficos
Autores principales: Shimizu, Kanako, Kurosawa, Yuri, Taniguchi, Masaru, Steinman, Ralph M., Fujii, Shin-ichiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118481/
https://www.ncbi.nlm.nih.gov/pubmed/17923500
http://dx.doi.org/10.1084/jem.20070458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118481/
https://www.ncbi.nlm.nih.gov/pubmed/17923500
http://dx.doi.org/10.1084/jem.20070458

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