BCL11B is required for positive selection and survival of double-positive thymocytes

Transcriptional control of gene expression in double-positive (DP) thymocytes remains poorly understood. We show that the transcription factor BCL11B plays a critical role in DP thymocytes by controlling positive selection of both CD4 and CD8 lineages. BCL11B-deficient DP thymocytes rearrange T cell...

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Detalles Bibliográficos
Autores principales: Albu, Diana I., Feng, Dongyun, Bhattacharya, Debarati, Jenkins, Nancy A., Copeland, Neal G., Liu, Pentao, Avram, Dorina
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118514/
https://www.ncbi.nlm.nih.gov/pubmed/17998389
http://dx.doi.org/10.1084/jem.20070863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118514/
https://www.ncbi.nlm.nih.gov/pubmed/17998389
http://dx.doi.org/10.1084/jem.20070863

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