Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

Interleukin-1 receptor–associated kinase 4 (IRAK-4) was reported to be essential for the Toll-like receptor (TLR)– and T cell receptor (TCR)–mediated signaling leading to the activation of nuclear factor κB (NF-κB). However, the importance of kinase activity of IRAK family members is unclear. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kawagoe, Tatsukata, Sato, Shintaro, Jung, Andreas, Yamamoto, Masahiro, Matsui, Kosuke, Kato, Hiroki, Uematsu, Satoshi, Takeuchi, Osamu, Akira, Shizuo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118579/
https://www.ncbi.nlm.nih.gov/pubmed/17485511
http://dx.doi.org/10.1084/jem.20061523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118579/
https://www.ncbi.nlm.nih.gov/pubmed/17485511
http://dx.doi.org/10.1084/jem.20061523

Ejemplares similares