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Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function
During an immune response, activated antigen (Ag)-specific T cells condition dendritic cells (DCs) to enhance DC function and survival within the inflamed draining lymph node (LN). It has been difficult to ascertain the role of the tumor necrosis factor (TNF) superfamily member lymphotoxin-αβ (LTαβ)...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118582/ https://www.ncbi.nlm.nih.gov/pubmed/17452522 http://dx.doi.org/10.1084/jem.20061968 |
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author | Summers-deLuca, Leslie E. McCarthy, Douglas D. Cosovic, Bojana Ward, Lesley A. Lo, Calvin C. Scheu, Stefanie Pfeffer, Klaus Gommerman, Jennifer L. |
author_facet | Summers-deLuca, Leslie E. McCarthy, Douglas D. Cosovic, Bojana Ward, Lesley A. Lo, Calvin C. Scheu, Stefanie Pfeffer, Klaus Gommerman, Jennifer L. |
author_sort | Summers-deLuca, Leslie E. |
collection | PubMed |
description | During an immune response, activated antigen (Ag)-specific T cells condition dendritic cells (DCs) to enhance DC function and survival within the inflamed draining lymph node (LN). It has been difficult to ascertain the role of the tumor necrosis factor (TNF) superfamily member lymphotoxin-αβ (LTαβ) in this process because signaling through the LTβ-receptor (LTβR) controls multiple aspects of lymphoid tissue organization. To resolve this, we have used an in vivo system where the expression of TNF family ligands is manipulated only on the Ag-specific T cells that interact with and condition Ag-bearing DCs. We report that LTαβ is a critical participant required for optimal DC function, independent of its described role in maintaining lymphoid tissue organization. In the absence of LTαβ or CD40L on Ag-specific T cells, DC dysfunction could be rescued in vivo via CD40 or LTβR stimulation, respectively, suggesting that these two pathways cooperate for optimal DC conditioning. |
format | Text |
id | pubmed-2118582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21185822007-12-13 Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function Summers-deLuca, Leslie E. McCarthy, Douglas D. Cosovic, Bojana Ward, Lesley A. Lo, Calvin C. Scheu, Stefanie Pfeffer, Klaus Gommerman, Jennifer L. J Exp Med Articles During an immune response, activated antigen (Ag)-specific T cells condition dendritic cells (DCs) to enhance DC function and survival within the inflamed draining lymph node (LN). It has been difficult to ascertain the role of the tumor necrosis factor (TNF) superfamily member lymphotoxin-αβ (LTαβ) in this process because signaling through the LTβ-receptor (LTβR) controls multiple aspects of lymphoid tissue organization. To resolve this, we have used an in vivo system where the expression of TNF family ligands is manipulated only on the Ag-specific T cells that interact with and condition Ag-bearing DCs. We report that LTαβ is a critical participant required for optimal DC function, independent of its described role in maintaining lymphoid tissue organization. In the absence of LTαβ or CD40L on Ag-specific T cells, DC dysfunction could be rescued in vivo via CD40 or LTβR stimulation, respectively, suggesting that these two pathways cooperate for optimal DC conditioning. The Rockefeller University Press 2007-05-14 /pmc/articles/PMC2118582/ /pubmed/17452522 http://dx.doi.org/10.1084/jem.20061968 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Summers-deLuca, Leslie E. McCarthy, Douglas D. Cosovic, Bojana Ward, Lesley A. Lo, Calvin C. Scheu, Stefanie Pfeffer, Klaus Gommerman, Jennifer L. Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function |
title | Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function |
title_full | Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function |
title_fullStr | Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function |
title_full_unstemmed | Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function |
title_short | Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function |
title_sort | expression of lymphotoxin-αβ on antigen-specific t cells is required for dc function |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118582/ https://www.ncbi.nlm.nih.gov/pubmed/17452522 http://dx.doi.org/10.1084/jem.20061968 |
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