DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model

Tumor suppressor p53-dependent apoptosis is critical in suppressing tumorigenesis. Previously, we reported that DNA double-strand breaks (DSBs) at the V(D)J recombination loci induced genomic instability in the developing lymphocytes of nonhomologous end-joining (NHEJ)–deficient, p53-deficient mice,...

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Detalles Bibliográficos
Autores principales: Van Nguyen, Thang, Puebla-Osorio, Nahum, Pang, Hui, Dujka, Melanie E., Zhu, Chengming
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118600/
https://www.ncbi.nlm.nih.gov/pubmed/17535972
http://dx.doi.org/10.1084/jem.20062453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118600/
https://www.ncbi.nlm.nih.gov/pubmed/17535972
http://dx.doi.org/10.1084/jem.20062453

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