Cargando…

DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model

Tumor suppressor p53-dependent apoptosis is critical in suppressing tumorigenesis. Previously, we reported that DNA double-strand breaks (DSBs) at the V(D)J recombination loci induced genomic instability in the developing lymphocytes of nonhomologous end-joining (NHEJ)–deficient, p53-deficient mice,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Van Nguyen, Thang, Puebla-Osorio, Nahum, Pang, Hui, Dujka, Melanie E., Zhu, Chengming
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118600/ https://www.ncbi.nlm.nih.gov/pubmed/17535972 http://dx.doi.org/10.1084/jem.20062453

Ejemplares similares

The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence
por: Li, Xiaoman, et al.
Publicado: (2013)

Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice
por: Tavana, Omid, et al.
Publicado: (2010)

Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis
por: De Blander, Hadrien, et al.
Publicado: (2021)

DNA Damage, Cellular Senescence in Health and Disease
por: Neidernhofer, Laura
Publicado: (2020)

Ku70 Functions in Addition to Nonhomologous End Joining in Pancreatic β-Cells: A Connection to β-Catenin Regulation
por: Tavana, Omid, et al.
Publicado: (2013)

Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response
por: Du, Hekang, et al.
Publicado: (2023)

SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC
por: Lee, Namgyu, et al.
Publicado: (2016)

A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis
por: Meang, Moon Kee, et al.
Publicado: (2022)

Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells
por: Garcia-Arias, Juan Manuel, et al.
Publicado: (2023)

DNA damage, cellular senescence and organismal ageing: causal or correlative?
por: Chen, Jian-Hua, et al.
Publicado: (2007)

The impact of cellular senescence and DNA damage on colorectal tumour progression
por: Angell, Helen K, et al.
Publicado: (2013)

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
por: Passos, João F., et al.
Publicado: (2007)

DNA damage-induced degradation of Sp1 promotes cellular senescence
por: Swift, Michelle L., et al.
Publicado: (2021)

Sesamin Metabolites Suppress the Induction of Cellular Senescence
por: Araki, Chie, et al.
Publicado: (2023)

Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice
por: Puebla-Osorio, Nahum, et al.
Publicado: (2011)

LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence
por: Wang, Haibin, et al.
Publicado: (2017)

Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine
por: Wang, Linglu, et al.
Publicado: (2022)

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
por: Nakamura, Asako J, et al.
Publicado: (2008)

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling
por: Blazkova, Hana, et al.
Publicado: (2010)

Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence
por: Ao, Ying, et al.
Publicado: (2023)

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
por: Ogrodnik, Mikolaj, et al.
Publicado: (2018)

Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence
por: Wang, Haibin, et al.
Publicado: (2018)

SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis
por: De Lope, Cristina, et al.
Publicado: (2019)

Role of Senescence in Tumorigenesis and Anticancer Therapy
por: Stoczynska-Fidelus, Ewelina, et al.
Publicado: (2022)

Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity
por: Xia, Jing, et al.
Publicado: (2023)

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
por: Rashidieh, Behnam, et al.
Publicado: (2023)

Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation
por: Zhang, Xurui, et al.
Publicado: (2016)

Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity
por: Wang, Hanfeng, et al.
Publicado: (2022)

DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology
por: Xiong, Hao, et al.
Publicado: (2022)

DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
por: Wu, Xinna, et al.
Publicado: (2023)

A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence
por: Kang, Taekyu, et al.
Publicado: (2023)

Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells
por: Puebla-Osorio, N, et al.
Publicado: (2015)

Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
por: Luna, Carlos, et al.
Publicado: (2016)

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling
por: Espinosa-Diez, Cristina, et al.
Publicado: (2018)

Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence
por: Zhang, Yujie, et al.
Publicado: (2020)

WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression
por: Yan, Jia, et al.
Publicado: (2023)

Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis
Publicado: (1992)

Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells
por: Damiani, Elisabetta, et al.
Publicado: (2015)

Tissue specificity of DNA damage response and tumorigenesis
por: Sun, Siman, et al.
Publicado: (2019)

Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis
por: Tran, Phuoc T., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7jbj9ee4muarr4gs0l7pi48ijf