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CTLA-4: From conflict to clinic
CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118622/ https://www.ncbi.nlm.nih.gov/pubmed/17632849 http://dx.doi.org/10.1084/jem.2046fta |