CTLA-4: From conflict to clinic

CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as...

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Detalles Bibliográficos
Autor principal: Bashyam, Hema
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
From the Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118622/
https://www.ncbi.nlm.nih.gov/pubmed/17632849
http://dx.doi.org/10.1084/jem.2046fta
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author Bashyam, Hema
author_facet Bashyam, Hema
author_sort Bashyam, Hema
collection PubMed
description CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as a target for antitumor therapy and as a soluble inhibitor of autoimmunity.
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spelling pubmed-21186222007-12-13 CTLA-4: From conflict to clinic Bashyam, Hema J Exp Med From the Archive CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as a target for antitumor therapy and as a soluble inhibitor of autoimmunity. The Rockefeller University Press 2007-06-11 /pmc/articles/PMC2118622/ /pubmed/17632849 http://dx.doi.org/10.1084/jem.2046fta Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle From the Archive
Bashyam, Hema
CTLA-4: From conflict to clinic
title CTLA-4: From conflict to clinic
title_full CTLA-4: From conflict to clinic
title_fullStr CTLA-4: From conflict to clinic
title_full_unstemmed CTLA-4: From conflict to clinic
title_short CTLA-4: From conflict to clinic
title_sort ctla-4: from conflict to clinic
topic From the Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118622/
https://www.ncbi.nlm.nih.gov/pubmed/17632849
http://dx.doi.org/10.1084/jem.2046fta
work_keys_str_mv AT bashyamhema ctla4fromconflicttoclinic

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