Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

We examined the role of the antiapoptotic molecule Bcl-2 in combating the proapoptotic molecule Bim in control of naive and memory T cell homeostasis using Bcl-2(−/−) mice that were additionally deficient in one or both alleles of Bim. Naive T cells were significantly decreased in Bim(+/−)Bcl-2(−/−)...

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Detalles Bibliográficos
Autores principales: Wojciechowski, Sara, Tripathi, Pulak, Bourdeau, Tristan, Acero, Luis, Grimes, H. Leighton, Katz, Jonathan D., Finkelman, Fred D., Hildeman, David A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118628/
https://www.ncbi.nlm.nih.gov/pubmed/17591857
http://dx.doi.org/10.1084/jem.20070618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118628/
https://www.ncbi.nlm.nih.gov/pubmed/17591857
http://dx.doi.org/10.1084/jem.20070618

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