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CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Hyper-IgM (HIGM) syndromes are primary immunodeficiencies characterized by defects of class switch recombination and somatic hypermutation. HIGM patients who carry mutations in the CD40-ligand (CD40L) gene expressed by CD4(+) T cells suffer from recurrent infections and often develop autoimmune diso...

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Detalles Bibliográficos
Autores principales:	Hervé, Maxime, Isnardi, Isabelle, Ng, Yen-shing, Bussel, James B., Ochs, Hans D., Cunningham-Rundles, Charlotte, Meffre, Eric
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118633/ https://www.ncbi.nlm.nih.gov/pubmed/17562816 http://dx.doi.org/10.1084/jem.20062287

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