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Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells
The contributions of different subsets of memory CD8(+) T cells to recall responses at mucosal sites of infection are poorly understood. Here, we analyzed the CD8(+) T cell recall responses to respiratory virus infection in mice and demonstrate that activation markers, such as CD27 and CD43, define...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118640/ https://www.ncbi.nlm.nih.gov/pubmed/17606632 http://dx.doi.org/10.1084/jem.20070322 |
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author | Hikono, Hirokazu Kohlmeier, Jacob E. Takamura, Shiki Wittmer, Susan T. Roberts, Alan D. Woodland, David L. |
author_facet | Hikono, Hirokazu Kohlmeier, Jacob E. Takamura, Shiki Wittmer, Susan T. Roberts, Alan D. Woodland, David L. |
author_sort | Hikono, Hirokazu |
collection | PubMed |
description | The contributions of different subsets of memory CD8(+) T cells to recall responses at mucosal sites of infection are poorly understood. Here, we analyzed the CD8(+) T cell recall responses to respiratory virus infection in mice and demonstrate that activation markers, such as CD27 and CD43, define three distinct subpopulations of memory CD8(+) T cells that differ in their capacities to mount recall responses. These subpopulations are distinct from effector– and central–memory subsets, coordinately express other markers associated with activation status, including CXCR3, CD127, and killer cell lectin-like receptor G1, and are superior to CD62L in predicting the capacity of memory T cells to mediate recall responses. Furthermore, the capacity of vaccines to elicit these memory T cell subpopulations predicted the efficacy of the recall response. These findings extend our understanding of how recall responses are generated and suggest that activation and migration markers define distinct, and unrelated, characteristics of memory T cells. |
format | Text |
id | pubmed-2118640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21186402008-01-09 Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells Hikono, Hirokazu Kohlmeier, Jacob E. Takamura, Shiki Wittmer, Susan T. Roberts, Alan D. Woodland, David L. J Exp Med Articles The contributions of different subsets of memory CD8(+) T cells to recall responses at mucosal sites of infection are poorly understood. Here, we analyzed the CD8(+) T cell recall responses to respiratory virus infection in mice and demonstrate that activation markers, such as CD27 and CD43, define three distinct subpopulations of memory CD8(+) T cells that differ in their capacities to mount recall responses. These subpopulations are distinct from effector– and central–memory subsets, coordinately express other markers associated with activation status, including CXCR3, CD127, and killer cell lectin-like receptor G1, and are superior to CD62L in predicting the capacity of memory T cells to mediate recall responses. Furthermore, the capacity of vaccines to elicit these memory T cell subpopulations predicted the efficacy of the recall response. These findings extend our understanding of how recall responses are generated and suggest that activation and migration markers define distinct, and unrelated, characteristics of memory T cells. The Rockefeller University Press 2007-07-09 /pmc/articles/PMC2118640/ /pubmed/17606632 http://dx.doi.org/10.1084/jem.20070322 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Hikono, Hirokazu Kohlmeier, Jacob E. Takamura, Shiki Wittmer, Susan T. Roberts, Alan D. Woodland, David L. Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells |
title | Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells |
title_full | Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells |
title_fullStr | Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells |
title_full_unstemmed | Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells |
title_short | Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8(+) T cells |
title_sort | activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory cd8(+) t cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118640/ https://www.ncbi.nlm.nih.gov/pubmed/17606632 http://dx.doi.org/10.1084/jem.20070322 |
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