Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

Cerebrovascular dysfunction contributes to the pathology and progression of Alzheimer's disease (AD), but the mechanisms are not completely understood. Using transgenic mouse models of AD (TgCRND8, PDAPP, and Tg2576), we evaluated blood–brain barrier damage and the role of fibrin and fibrinolys...

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Detalles Bibliográficos
Autores principales: Paul, Justin, Strickland, Sidney, Melchor, Jerry P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118680/
https://www.ncbi.nlm.nih.gov/pubmed/17664291
http://dx.doi.org/10.1084/jem.20070304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118680/
https://www.ncbi.nlm.nih.gov/pubmed/17664291
http://dx.doi.org/10.1084/jem.20070304

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